Journal article
Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis
Chemical Society reviews, Vol.53(1), pp.137-162
01/02/2024
PMID: 38018371
Abstract
Natural metalloenzymes with astonishing reaction activity and specificity underpin essential life transformations. Nevertheless, enzymes only operate under mild conditions to keep sophisticated structures active, limiting their potential applications. Artificial metalloenzymes that recapitulate the catalytic activity of enzymes can not only circumvent the enzymatic fragility but also bring versatile functions into practice. Among them, metal–organic frameworks (MOFs) featuring diverse and site-isolated metal sites and supramolecular structures have emerged as promising candidates for metalloenzymes to move toward unparalleled properties and behaviour of enzymes. In this review, we systematically summarize the significant advances in MOF-based metalloenzyme mimics with a special emphasis on active pocket engineering at the atomic level, including primary catalytic sites and secondary coordination spheres. Then, the deep understanding of catalytic mechanisms and their advanced applications are discussed. Finally, a perspective on this emerging frontier research is provided to advance bioinspired catalysis.
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Details
- Title
- Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis
- Creators
- Weiqing Xu - Central China Normal UniversityYu Wu - Central China Normal UniversityWenling Gu - Central China Normal UniversityDan Du - Washington State UniversityYuehe Lin - Washington State UniversityChengzhou Zhu - Central China Normal University
- Publication Details
- Chemical Society reviews, Vol.53(1), pp.137-162
- Academic Unit
- School of Mechanical and Materials Engineering
- Number of pages
- 26
- Identifiers
- 99901227840701842
- Language
- English
- Resource Type
- Journal article