Journal article
Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?
Nature reviews. Microbiology, Vol.13(2), pp.71-82
02/2015
Handle:
https://hdl.handle.net/2376/105988
PMID: 25534809
Abstract
The unfolded protein response (UPR) is a cytoprotective response that is aimed at restoring cellular homeostasis following physiological stress exerted on the endoplasmic reticulum (ER), which also invokes innate immune signalling in response to invading microorganisms. Although it has been known for some time that the UPR is modulated by various viruses, recent evidence indicates that it also has multiple roles during bacterial infections. In this Review, we describe how bacteria interact with the ER, including how bacteria induce the UPR, how subversion of the UPR promotes bacterial proliferation and how the UPR contributes to innate immune responses against invading bacteria.
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Details
- Title
- Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?
- Creators
- Jean Celli - Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164, USARenée M Tsolis - Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Davis, California 95616, USA
- Publication Details
- Nature reviews. Microbiology, Vol.13(2), pp.71-82
- Academic Unit
- Paul G. Allen School for Global Animal Health
- Publisher
- England
- Grant note
- R01 AI109799 / NIAID NIH HHS AI090387 / NIAID NIH HHS R21 AI112649 / NIAID NIH HHS AI112649 / NIAID NIH HHS R21 AI097107 / NIAID NIH HHS AI050553 / NIAID NIH HHS AI097107 / NIAID NIH HHS R56 AI090387 / NIAID NIH HHS
- Identifiers
- 99900546848001842
- Language
- English
- Resource Type
- Journal article