Journal article
Bacterial subversion of host actin dynamics at the plasma membrane
Cellular microbiology, Vol.13(10), pp.1460-1469
10/2011
Handle:
https://hdl.handle.net/2376/106094
PMCID: PMC3174476
PMID: 21790944
Abstract
Invasion of non-phagocytic cells by a number of bacterial pathogens involves the subversion of the actin cytoskeletal remodelling machinery to produce actin-rich cell surface projections designed to engulf the bacteria. The signalling that occurs to induce these actin-rich structures has considerable overlap among a diverse group of bacteria. The molecular organization within these structures act in concert to internalize the invading pathogen. This dynamic process could be subdivided into three acts - actin recruitment, engulfment, and finally, actin disassembly/internalization. This review will present the current state of knowledge of the molecular processes involved in each stage of bacterial invasion, and provide a perspective that highlights the temporal and spatial control of actin remodelling that occurs during bacterial invasion.
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Details
- Title
- Bacterial subversion of host actin dynamics at the plasma membrane
- Creators
- Rey Carabeo - Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK. r.carabeo@imperial.ac.uk
- Publication Details
- Cellular microbiology, Vol.13(10), pp.1460-1469
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- England
- Grant note
- R01 AI065545 / NIAID NIH HHS R01 AI065545-05 / NIAID NIH HHS Medical Research Council G0900213 / Medical Research Council
- Identifiers
- 99900547060101842
- Language
- English
- Resource Type
- Journal article