Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides

Fang Zhu; Hemant Gujar; Jennifer R Gordon; Kenneth F Haynes; Michael F Potter; Subba R Palli

doi:10.1038/srep01456

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Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides

Journal article

Open access

Peer reviewed

Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides

Fang Zhu, Hemant Gujar, Jennifer R Gordon, Kenneth F Haynes, Michael F Potter and Subba R Palli

Scientific reports, Vol.3(1), pp.1456-1456

2013

DOI: https://doi.org/10.1038/srep01456

Handle:

https://hdl.handle.net/2376/106484

PMCID: PMC3596983

PMID: 23492626

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https://doi.org/10.1038/srep01456View

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Abstract

Pyrethrins - toxicity

Cytochrome P-450 Enzyme Inhibitors

Cytochrome P-450 Enzyme System - metabolism

Insect Proteins - genetics

Insecticide Resistance - genetics

Gene Expression Profiling

Insect Proteins - antagonists & inhibitors

Bedbugs - drug effects

Bedbugs - metabolism

Animals

ATP-Binding Cassette Transporters - genetics

RNA Interference

ATP-Binding Cassette Transporters - metabolism

Cytochrome P-450 Enzyme System - genetics

Female

Mutation

Genome

Insect Proteins - metabolism

Insecticides - toxicity

Bedbugs - genetics

Recent advances in genomic and post-genomic technologies have facilitated a genome-wide analysis of the insecticide resistance-associated genes in insects. Through bed bug, Cimex lectularius transcriptome analysis, we identified 14 molecular markers associated with pyrethroid resistance. Our studies revealed that most of the resistance-associated genes functioning in diverse mechanisms are expressed in the epidermal layer of the integument, which could prevent or slow down the toxin from reaching the target sites on nerve cells, where an additional layer of resistance (kdr) is possible. This strategy evolved in bed bugs is based on their unique morphological, physiological and behavioral characteristics and has not been reported in any other insect species. RNA interference-aided knockdown of resistance associated genes showed the relative contribution of each mechanism towards overall resistance development. Understanding the complexity of adaptive strategies employed by bed bugs will help in designing the most effective and sustainable bed bug control methods.

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Title: Bed bugs evolved unique adaptive strategy to resist pyrethroid insecticides
Creators: Fang Zhu - Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
Hemant Gujar
Jennifer R Gordon
Kenneth F Haynes
Michael F Potter
Subba R Palli
Publication Details: Scientific reports, Vol.3(1), pp.1456-1456
Publisher: England
Identifiers: 99900546543401842
Language: English
Resource Type: Journal article