Journal article
Benzothiazole Sulfinate: A Sulfinic Acid Transfer Reagent under Oxidation-Free Conditions
Organic letters, Vol.19(14), pp.3819-3822
07/21/2017
Handle:
https://hdl.handle.net/2376/106113
PMCID: PMC5863730
PMID: 28670905
Abstract
Sulfinic acids are commonly encountered intermediates found in natural product synthesis and medicinal chemistry. However, because of high reactivity, instability, and harsh reaction conditions, they are difficult to synthesize. Herein we have developed an oxidation-free method to produce sulfinic acids and sulfinate salts using 2-sulfinyl benzothiazole (BTS). We have also demonstrated the synthetic usefulness by developing one-pot syntheses of sulfones and sulfonamides.
Metrics
9 Record Views
Details
- Title
- Benzothiazole Sulfinate: A Sulfinic Acid Transfer Reagent under Oxidation-Free Conditions
- Creators
- Jacob J Day - Department of Chemistry, Washington State University , Pullman, Washington 99164, United StatesDeshka L Neill - Department of Chemistry, Washington State University , Pullman, Washington 99164, United StatesShi Xu - Department of Chemistry, Washington State University , Pullman, Washington 99164, United StatesMing Xian - Department of Chemistry, Washington State University , Pullman, Washington 99164, United States
- Publication Details
- Organic letters, Vol.19(14), pp.3819-3822
- Academic Unit
- Chemistry, Department of
- Publisher
- United States
- Grant note
- F31 HL137233 / NHLBI NIH HHS
- Identifiers
- 99900546806501842
- Language
- English
- Resource Type
- Journal article