Journal article
Benzothiazole Sulfinate: a Water-Soluble and Slow-Releasing Sulfur Dioxide Donor
ACS chemical biology, Vol.11(6), pp.1647-1651
06/17/2016
Handle:
https://hdl.handle.net/2376/107254
PMID: 27031093
Abstract
Sulfur dioxide (SO2) has long been considered a toxic environmental pollutant and byproduct of industrial processing. Recently it has become evident that SO2 may also have regulatory functions in mammalian pulmonary systems. However, the study of these effects has proven to be challenging due to the difficulty in administering SO2 in a reliable manner. In this work, we report the discovery of a new pH-dependent and water-soluble SO2 donor, benzothiazole sulfinate (BTS). We have found BTS to have slow and sustained SO2 release at physiological pH. Additionally, we have explored its vasorelaxation properties as compared to the authentic SO2 gas solutions. The slow release of BTS should make it a useful tool for the study of endogenously generated SO2.
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Details
- Title
- Benzothiazole Sulfinate: a Water-Soluble and Slow-Releasing Sulfur Dioxide Donor
- Creators
- Jacob J Day - Department of Chemistry, Washington State University , Pullman, Washington 99164, United StatesZhenhua Yang - Institute of Environmental Science, Shanxi University , Taiyuan, Shanxi 030006, ChinaWei Chen - Department of Chemistry, Washington State University , Pullman, Washington 99164, United StatesArmando Pacheco - Department of Chemistry, Washington State University , Pullman, Washington 99164, United StatesMing Xian - Institute of Environmental Science, Shanxi University , Taiyuan, Shanxi 030006, China
- Publication Details
- ACS chemical biology, Vol.11(6), pp.1647-1651
- Academic Unit
- Chemistry, Department of
- Publisher
- United States
- Grant note
- R01 HL116571 / NHLBI NIH HHS
- Identifiers
- 99900547191201842
- Language
- English
- Resource Type
- Journal article