Journal article
Bioinspired Peptoid Nanotubes for Targeted Tumor Cell Imaging and Chemo-Photodynamic Therapy
Small (Weinheim an der Bergstrasse, Germany), Vol.15(43), pp.e1902485-n/a
10/01/2019
PMID: 31468663
Abstract
Substantial progress has been made in applying nanotubes in biomedical applications such as bioimaging and drug delivery due to their unique architecture, characterized by very large internal surface areas and high aspect ratios. However, the biomedical applications of organic nanotubes, especially for those assembled from sequence-defined molecules, are very uncommon. In this paper, the synthesis of two new peptoid nanotubes (PepTs1 and PepTs2) is reported by using sequence-defined and ligand-tagged peptoids as building blocks. These nanotubes are highly robust due to sharing a similar structure to those of nontagged ones, and offer great potential to hold guest molecules for biomedical applications. The findings indicate that peptoid nanotubes loaded with doxorubicin drugs are promising candidates for targeted tumor cell imaging and chemo-photodynamic therapy.
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Details
- Title
- Bioinspired Peptoid Nanotubes for Targeted Tumor Cell Imaging and Chemo-Photodynamic Therapy
- Creators
- Yanan Luo - Washington State UniversityYang Song - Washington State UniversityMingming Wang - Pacific Northwest Natl Lab, Phys Sci Div, Richland, WA 99352 USATengyue Jian - Pacific Northwest Natl Lab, Phys Sci Div, Richland, WA 99352 USAShichao Ding - Washington State UniversityPeng Mu - Pacific Northwest Natl Lab, Phys Sci Div, Richland, WA 99352 USAZhihao Liao - Pacific Northwest Natl Lab, Phys Sci Div, Richland, WA 99352 USAQiurong Shi - Washington State UniversityXiaoli Cai - Washington State UniversityHaibao Jin - Pacific Northwest Natl Lab, Phys Sci Div, Richland, WA 99352 USADan Du - Washington State UniversityWen-Ji Dong - Washington State Univ, Chem Engn & Bioengn, Pullman, WA 99164 USAChun-Long Chen - Pacific Northwest Natl Lab, Phys Sci Div, Richland, WA 99352 USAYuehe Lin - Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA
- Publication Details
- Small (Weinheim an der Bergstrasse, Germany), Vol.15(43), pp.e1902485-n/a
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- DE-AC05-76RL01830 / Department of Energy; United States Department of Energy (DOE) Molecular Foundry, at Lawrence Berkeley National Laboratory Washington State University Materials Synthesis and Simulation Across Scales (MS3) Initiative through the LDRD fund at Pacific Northwest National Laboratory (PNNL) DE-SC0019288 / US Department of Energy, Office of Science, Office of Basic Energy Sciences, as part of the Energy Frontier Research Centers program: CSSAS-The Center for the Science of Synthesis Across Scales; United States Department of Energy (DOE) U.S. Department of Energy, Office of Basic Energy Sciences, Biomolecular Materials Program at PNNL; United States Department of Energy (DOE)
- Identifiers
- 99901227637801842
- Language
- English
- Resource Type
- Journal article