Journal article
Biomedical Potential of Ultrafine Ag/AgCl Nanoparticles Coated on Graphene with Special Reference to Antimicrobial Performances and Burn Wound Healing
ACS applied materials & interfaces, Vol.8(24), pp.15067-15075
06/22/2016
Handle:
https://hdl.handle.net/2376/106683
PMID: 27064187
Abstract
In recent years, researchers have proven the release of silver ions (Ag+) from silver nanoparticles (Ag NPs) significantly affects their toxicity to bacteria and other organisms. Due to the difficulty in maintaining a steady flux of a high concentration of Ag+, it is still challenging to develop a highly efficient, stable, and biocompatible Ag NP-based antimicrobial material. To circumvent this issue, we developed a new Ag-based bactericide through the fabrication of sunlight-driven and ultrafine silver/silver chloride anchored on reduced graphene oxide (Ag/AgCl/rGO). This stable Ag/AgCl nanophotocatalyst with negligible release of Ag+ generated a high amount of oxidative radicals, killing the bacteria, thus achieving both high bactericidal efficiency and stability. Moreover, functionalization of the nanomaterial with poly(diallyldimethylammonium chloride) (PDDA) gives it a highly adsorptive capacity, which allows it to capture the bacteria and possibly enhances the bactericidal activity. In vivo histopathological studies showed that the Ag/AgCl/rGO nanomaterial could obviously promote the regeneration of the epidermis, which indicated the good biomedical potential of Ag/AgCl/rGO nanomaterial in burn wound healing.
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Details
- Title
- Biomedical Potential of Ultrafine Ag/AgCl Nanoparticles Coated on Graphene with Special Reference to Antimicrobial Performances and Burn Wound Healing
- Creators
- Yazhou ZhouRu ChenTingting HeKai XuDan DuNan ZhaoXiaonong ChengJuan YangHaifeng ShiYuehe Lin
- Publication Details
- ACS applied materials & interfaces, Vol.8(24), pp.15067-15075
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- American Chemical Society
- Identifiers
- 99900546766001842
- Language
- English
- Resource Type
- Journal article