Files and links (1)
Rights Statements InC/1.0 , Open Access
Journal article
BlaCMY-2 positive Inc A/C plasmids from Escherichia coli and Salmonella enterica are a distinct component of a larger lineage of plasmids
Antimicrobial agents and chemotherapy : AAC., Vol.54(2), pp.590-596
11/2009
Handle:
https://hdl.handle.net/2376/5994
Abstract
Large multidrug resistance plasmids of the A/C incompatibility complex (IncA/C) have been found in a diverse group of Gram-negative commensal and pathogenic bacteria. We present three completed sequences from IncA/C plasmids that originated from Escherichia coli (cattle) and Salmonella enterica serovar Newport (human) and that carry the cephamycinase gene blaCMY-2. These large plasmids (148 to 166 kbp) share extensive sequence identity and synteny. The most divergent plasmid, peH4H, has lost several conjugation-related genes and has gained a kanamycin resistance region. Two of the plasmids (pAM04528 and peH4H) harbor two copies of blaCMY-2, while the third plasmid (pAR060302) harbors a single copy of the gene. The majority of single-nucleotide polymorphisms comprise nonsynonymous mutations in floR. A comparative analysis of these plasmids with five other published IncA/C plasmids showed that the blaCMY-2 plasmids from E. coli and S. enterica are genetically distinct from those originating from Yersinia pestis and Photobacterium damselae and distal to one originating from Yersinia ruckeri. While the overall similarity of these plasmids supports the likelihood of recent movements among E. coli and S. enterica hosts, their greater divergence from Y. pestis or Y. ruckeri suggests less recent plasmid transfer among these pathogen groups.
Metrics
31 File views/ downloads
64 Record Views
Details
- Title
- BlaCMY-2 positive Inc A/C plasmids from Escherichia coli and Salmonella enterica are a distinct component of a larger lineage of plasmids
- Creators
- Douglas R. Call (Author)Randall S. Singer (Author)Da Meng (Author)Shira L. Broschat (Author)Lisa H. Orfe (Author)Janet M. Anderson (Author)David R. Herndon (Author)Lowell S. Kappmeyer (Author)Joshua B. Daniels (Author)Thomas E Besser (Author)
- Publication Details
- Antimicrobial agents and chemotherapy : AAC., Vol.54(2), pp.590-596
- Academic Unit
- Electrical Engineering and Computer Science, School of; Paul G. Allen School for Global Animal Health
- Identifiers
- 99900501568901842
- Copyright
- In copyright ; openAccess ; http://rightsstatements.org/vocab/InC/1.0/ ; http://purl.org/eprint/accessRights/OpenAccess
- Language
- English
- Resource Type
- Journal article