Journal article
Body Mass Index, Cigarette Smoking, and Alcohol Consumption and Cancers of the Oral Cavity, Pharynx, and Larynx: Modeling Odds Ratios in Pooled Case-Control Data
American journal of epidemiology, Vol.171(12), pp.1250-1261
2010
Handle:
https://hdl.handle.net/2376/105408
PMCID: PMC2915496
PMID: 20494999
Abstract
Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of < 10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer.
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Details
- Title
- Body Mass Index, Cigarette Smoking, and Alcohol Consumption and Cancers of the Oral Cavity, Pharynx, and Larynx: Modeling Odds Ratios in Pooled Case-Control Data
- Creators
- Jay H LUBIN - National Cancer Institute, Bethesda, Maryland, United StatesMia M GAUDET - Department of Epidemiology and Population Health and Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, New York, New York, United StatesAlexander W DAUDT - Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilEleonora FABIANOVA - Specialized State Health Institute, Banská Bystrica, SlovakiaLeticia FERNANDEZ - Institute of Oncology and Radiobiology, Havana, CubaVictor WÜNSCH-FILHO - Universidade de São Paulo, São Paulo, BrazilSilvia FRANCESCHI - International Agency for Research on Cancer, Lyon, FranceRolando HERRERO - Instituto de Investigación Epidemiológica, San José, Costa RicaSergio KOIFMAN - Escola Nacional de Saude Publica, Fundaçao Oswaldo Cruz, Rio de Janeiro, BrazilCarlo LA VECCHIA - Istituto di Ricerche Farmacologiche Mario Negri and University of Milan, Milan, ItalyPhilip LAZARUS - Penn State College of Medicine, Hershey, Pennsylvania, United StatesFabio LEVI - Institut de médecine sociale et préventive, Université de Lausanne, Lausanne, SwitzerlandAndrew F OLSHAN - Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, United StatesJolanta LISSOWSKA - Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, PolandLoan NICOLAE MATES - Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaElena MATOS - Angel H. Roffo Institute of Oncology, University of Buenos Aires, Buenos Aires, ArgentinaMichael MCCLEAN - School of Public Health, Boston University, Boston, Massachusetts, United StatesAna MENEZES - Universidade Federal de Pelotas, Pelotas, BrazilHal MORGENSTERN - Department of Epidemiology and Department of Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United StatesJoshua MUSCAT - Penn State College of Medicine, Hershey, Pennsylvania, United StatesJose ELUF - Universidade de São Paulo, São Paulo, BrazilMark P PURDUE - National Cancer Institute, Bethesda, Maryland, United StatesPeter RUDNAI - National Institute of Environmental Health, Budapest, HungaryKarl KELSEY - BioMedical Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United StatesStephen M SCHWARTZ - Fred Hutchinson Cancer Research Center, Seattle, Washington, United StatesOxana SHANGINA - Cancer Research Centre, Moscow, Russian FederationErich M STURGIS - University of Texas-M. D. Anderson Cancer Center, Houston, Texas, United StatesNeonilia SZESZENIA-DABROWSKA - Institute of Occupational Medicine, Lodz, PolandRenato TALAMINI - Epidemiology and Biostatistics Unit, Aviano Cancer Centre, Aviano, ItalyQINGYI QINGYI WEI - University of Texas-M. D. Anderson Cancer Center, Houston, Texas, United StatesDeborah WINN - National Cancer Institute, Bethesda, Maryland, United StatesZuo-Feng ZHANG - School of Public Health, University of California, Los Angeles, Los Angeles, California, United StatesMia HASHIBE - Department of Family and Preventive Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United StatesRichard B HAYES - Division of Epidemiology, Langone Medical Center, New York University, New York, New York, United StatesPaolo BOFFETTA - International Agency for Research on Cancer, Lyon, FrancePaul BRENNAN - International Agency for Research on Cancer, Lyon, FranceXavier CASTELLSAGUE - Institut Català d'Oncologia, IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Barcelona, SpainCHU CHU CHEN - Fred Hutchinson Cancer Research Center, Seattle, Washington, United StatesMaria Paula CURADO - International Agency for Research on Cancer, Lyon, FranceLuigino DAL MASO - Epidemiology and Biostatistics Unit, Aviano Cancer Centre, Aviano, Italy
- Publication Details
- American journal of epidemiology, Vol.171(12), pp.1250-1261
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- Oxford University Press; Cary, NC
- Number of pages
- 12
- Grant note
- National Cancer Institute, US Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32CA009142; ZIACP010181 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Identifiers
- 99900546612701842
- Language
- Russian
- Resource Type
- Journal article