Journal article
Body mass index and risk of head and neck cancer in a pooled analysis of case–control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium
International journal of epidemiology, Vol.39(4), pp.1091-1102
08/2010
Handle:
https://hdl.handle.net/2376/108688
PMCID: PMC2929351
PMID: 20123951
Abstract
Background
Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases.
Methods
We pooled data from 17 case–control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption.
Results
Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) ≤18.5 kg/m
2
(2.13, 1.75–2.58) and reduced for BMI >25.0–30.0 kg/m
2
(0.52, 0.44–0.60) and BMI ≥30 kg/m
2
(0.43, 0.33–0.57), compared with BMI >18.5–25.0 kg/m
2
. These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI ≤18.5 kg/m
2
was not modified by tobacco smoking or alcohol drinking, the inverse association for people with BMI > 25 kg/m
2
was present only in smokers and drinkers.
Conclusions
In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.
Metrics
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Details
- Title
- Body mass index and risk of head and neck cancer in a pooled analysis of case–control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium
- Creators
- Philip Lazarus - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYMia M Gaudet - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYAndrew F Olshan - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYShu-Chun Chuang - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYJulien Berthiller - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYZuo-Feng Zhang - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYJolanta Lissowska - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYDavid Zaridze - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYDeborah M Winn - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYQingyi Wei - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYRenato Talamini - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYNeolilia Szeszenia-Dabrowska - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYErich M Sturgis - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYStephen M Schwartz - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYPeter Rudnai - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYJose Eluf-Neto - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYJoshua Muscat - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYHal Morgenstern - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYAna Menezes - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYElena Matos - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYAlexandru Bucur - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYFabio Levi - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYCarlo La Vecchia - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYSergio Koifman - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYKarl Kelsey - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYRolando Herrero - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYRichard B Hayes - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYSilva Franceschi - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYVictor Wunsch-Filho - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYLeticia Fernandez - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYEleonora Fabianova - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYAlexander W Daudt - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYLuigino Dal Maso - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYMaria Paula Curado - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYChu Chen - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYXavier Castellsague - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYSimone Benhamou - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYPaolo Boffetta - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYPaul Brennan - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NYMia Hashibe - Departments of Epidemiology and Population Health and of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY
- Publication Details
- International journal of epidemiology, Vol.39(4), pp.1091-1102
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- Oxford University Press
- Number of pages
- 12
- Identifiers
- 99900547743101842
- Language
- English
- Resource Type
- Journal article