Bone cell–materials interactions and Ni ion release of anodized equiatomic NiTi alloy

Sheldon A Bernard; Vamsi Krishna Balla; Neal M Davies; Susmita Bose; Amit Bandyopadhyay

doi:10.1016/j.actbio.2011.01.004

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Bone cell–materials interactions and Ni ion release of anodized equiatomic NiTi alloy

Journal article

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Bone cell–materials interactions and Ni ion release of anodized equiatomic NiTi alloy

Sheldon A Bernard, Vamsi Krishna Balla, Neal M Davies, Susmita Bose and Amit Bandyopadhyay

Acta biomaterialia, Vol.7(4), pp.1902-1912

04/2011

DOI: https://doi.org/10.1016/j.actbio.2011.01.004

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https://hdl.handle.net/2376/111979

PMCID: PMC3048762

PMID: 21232641

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Abstract

Surface modification

Ni release

Nitinol

Anodization

Cell–material interactions

A laser processed NiTi alloy was anodized for different times in H2SO4 electrolyte with varying pH to create biocompatible surfaces with low Ni ion release as well as bioactive surfaces to enhance biocompatibility and bone cell–material interactions. The anodized surfaces were assessed for their in vitro cell–material interactions using human fetal osteoblast (hFOB) cells for 3, 7 and 11days, and Ni ion release up to 8weeks in simulated body fluids. The results were correlated with the surface morphologies of anodized surfaces characterized using field-emission scanning electron microscopy (FESEM). The results show that anodization creates a surface with nano/micro-roughness depending on the anodization conditions. The hydrophilicity of the NiTi surface was found to improve after anodization, as shown by the lower contact angles in cell medium, which dropped from 32° to <5°. The improved wettability of anodized surfaces is further corroborated by their high surface energy, comparable with that of commercially pure Ti. Relatively high surface energies, especially the polar component, and nano/micro surface features of anodized surfaces significantly increased the number of living cells and their adherence and growth on these surfaces. Finally, a significant drop in Ni ion release from 268±11 to 136±15ppb was observed for NiTi surfaces after anodization. This work indicates that anodization of a NiTi alloy has a positive influence on the surface energy and surface morphology, which in turn improves bone cell–material interactions and reduces Ni ion release in vitro.

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Title: Bone cell–materials interactions and Ni ion release of anodized equiatomic NiTi alloy
Creators: Sheldon A Bernard - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA
Vamsi Krishna Balla - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA
Neal M Davies - College of Pharmacy, Department of Pharmaceutical Sciences, Washington State University, Pullman, WA 99164, USA
Susmita Bose - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA
Amit Bandyopadhyay - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA
Publication Details: Acta biomaterialia, Vol.7(4), pp.1902-1912
Academic Unit: Mechanical and Materials Engineering, School of
Publisher: Elsevier Ltd
Identifiers: 99900547755101842
Language: English
Resource Type: Journal article