Journal article
Brain angiotensin: Critical role in the ongoing regulation of body fluid homeostasis and cardiovascular function
Peptides (New York, N.Y. : 1980), Vol.10(2), pp.261-264
1989
Handle:
https://hdl.handle.net/2376/108880
PMID: 2755868
Abstract
The existence of an endogenous brain-angiotensin system and its association with cardiovascular and body water regulation has been recognized for over a decade. Nevertheless, the importance of the brain-angiotensin system to the instantaneous regulation of these processes has not been firmly established. A 5-minute intracerebroventricular (ICV) infusion of the angiotensin antagonist, [Sar
1,Thr
8]-AII, effectively lowered the blood pressure in normotensive rats. Additionally, application of the selective aminopeptidase inhibitor, bestatin, given alone, resulted in a dramatic increase in blood pressure and a robust drinking response. Both effects were 100% blockable by [Sar
1,Thr
8]-AII pretreatment. Predictably, an aminopeptidase inhibitor, bestatin, greatly elongated the half-lives of AII and AIII in the cerebroventricles. Since neither of these treatments included the introduction of exogenous angiotensins, we have concluded that perturbations of the endogenous brain-angiotensin system are effective at rapidly influencing both cardiovascular and body fluid homeostasis, thus highlighting the paramount role played by brain angiotensin in their ongoing regulation.
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Details
- Title
- Brain angiotensin: Critical role in the ongoing regulation of body fluid homeostasis and cardiovascular function
- Creators
- J.W Harding - Department of Veterinary and Comparative Anatomy, Washington State University, Pullman, WA 99164 USAL.L Jensen - Department of Psychology Washington State University, Pullman, WA 99164 USAW.S Quirk - Department of Psychology Washington State University, Pullman, WA 99164 USAA.L Dewey - Department of Veterinary and Comparative Anatomy, Washington State University, Pullman, WA 99164 USAJ.W Wright - Department of Psychology Washington State University, Pullman, WA 99164 USA
- Publication Details
- Peptides (New York, N.Y. : 1980), Vol.10(2), pp.261-264
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547264001842
- Language
- English
- Resource Type
- Journal article