Journal article
Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.276(5), pp.R1334-R1338
05/01/1999
Handle:
https://hdl.handle.net/2376/114709
PMID: 10233024
Abstract
Various growth factors are involved in sleep regulation. Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family; it and its receptors are found in normal brain. Furthermore, cerebral cortical levels of BDNF mRNA have a diurnal variation and increase after sleep deprivation. Therefore, we investigated whether BDNF would promote sleep. Twenty-four male Sprague-Dawley rats (320–380 g) and 25 male New Zealand White rabbits (4.5–5.5 kg) were surgically implanted with electroencephalographic (EEG) electrodes, a brain thermistor, and a lateral intracerebroventricular cannula. The animals were injected intracerebroventricularly with pyrogen-free saline and, on a separate day, one of the following doses of BDNF: 25 or 250 ng in rabbits; 10, 50, or 250 ng in rats. The EEG, brain temperature, and motor activity were recorded for 23 h after the intracerebroventricular injections. BDNF increased time spent in non-rapid eye movement sleep (NREMS) in rats and rabbits and REMS in rabbits. Current results provide further evidence that various growth factors are involved in sleep regulation.
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Details
- Title
- Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits
- Creators
- Tetsuya Kushikata - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164Jidong Fang - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164James M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.276(5), pp.R1334-R1338
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900548125201842
- Language
- English
- Resource Type
- Journal article