Journal article
Brain-specific interleukin-1 receptor accessory protein in sleep regulation
Journal of applied physiology (1985), Vol.112(6), pp.1015-1022
03/15/2012
Handle:
https://hdl.handle.net/2376/114269
PMCID: PMC3311656
PMID: 22174404
Abstract
Interleukin (IL)-1β is involved in several brain functions, including sleep regulation. It promotes non-rapid eye movement (NREM) sleep via the IL-1 type I receptor. IL-1β/IL-1 receptor complex signaling requires adaptor proteins, e.g., the IL-1 receptor brain-specific accessory protein (AcPb). We have cloned and characterized rat AcPb, which shares substantial homologies with mouse AcPb and, compared with AcP, is preferentially expressed in the brain. Furthermore, rat somatosensory cortex AcPb mRNA varied across the day with sleep propensity, increased after sleep deprivation, and was induced by somnogenic doses of IL-1β. Duration of NREM sleep was slightly shorter and duration of REM sleep was slightly longer in AcPb knockout than wild-type mice. In response to lipopolysaccharide, which is used to induce IL-1β, sleep responses were exaggerated in AcPb knockout mice, suggesting that, in normal mice, inflammation-mediated sleep responses are attenuated by AcPb. We conclude that AcPb has a role in sleep responses to inflammatory stimuli and, possibly, in physiological sleep regulation.
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Details
- Title
- Brain-specific interleukin-1 receptor accessory protein in sleep regulation
- Creators
- Ping Taishi - Sleep and Performance Research Center, WWAMI Medical Education Program, Washington State University, Spokane; andChristopher J Davis - Sleep and Performance Research Center, WWAMI Medical Education Program, Washington State University, Spokane; andOmar Bayomy - Sleep and Performance Research Center, WWAMI Medical Education Program, Washington State University, Spokane; andMark R Zielinski - Sleep and Performance Research Center, WWAMI Medical Education Program, Washington State University, Spokane; andFan Liao - Sleep and Performance Research Center, WWAMI Medical Education Program, Washington State University, Spokane; andJames M Clinton - Sleep and Performance Research Center, WWAMI Medical Education Program, Washington State University, Spokane; andDirk E Smith - Department of Inflammation Research, Amgen, Seattle, WashingtonJames M Krueger - Sleep and Performance Research Center, WWAMI Medical Education Program, Washington State University, Spokane; and
- Publication Details
- Journal of applied physiology (1985), Vol.112(6), pp.1015-1022
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- American Physiological Society; Bethesda, MD
- Grant note
- NS-025378; NS-031453; HD-036520 / National Institutes of Health
- Identifiers
- 99900548058301842
- Language
- English
- Resource Type
- Journal article