Journal article
Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep
The American journal of physiology, Vol.250(1 Pt 2), pp.R96-103
01/1986
Handle:
https://hdl.handle.net/2376/104110
PMID: 3484616
Abstract
The effects of human interleukin 1 (IL 1) on the architecture of rabbit sleep-wake cycles and brain temperature (Tbr) changes coupled to states of vigilance were examined. Cerebral intraventricular infusion of IL 1 induced increased slow-wave sleep (SWS), increased electroencephalographic slow-wave (0.5-4 Hz) amplitudes, and fever. Heat-inactivated IL 1 failed to elicit these responses. IL 1 also significantly inhibited rapid-eye-movement (REM) sleep; however, inactivated IL 1 also reduced REM sleep; thus some of the IL 1-induced REM reduction may be related to the infusion process. The duration and number of sleep cycles (REM-to-REM interval) were unaffected by IL 1. Similarly, Tbr changes that normally occur during the transition from one arousal state to another remained unchanged after IL 1 infusion, even though rabbits were simultaneously febrile. We conclude that IL 1 selectively enhances SWS while leaving sleep cycles and Tbr changes coupled to states of vigilance undisturbed.
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Details
- Title
- Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep
- Creators
- J WalterD DavenneS ShohamC A DinarelloJ M Krueger
- Publication Details
- The American journal of physiology, Vol.250(1 Pt 2), pp.R96-103
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- NIH-GM-33268 / NIGMS NIH HHS NIH-BRSG-RR 5366 / NCRR NIH HHS NIH-AI-15614 / NIAID NIH HHS
- Identifiers
- 99900546687501842
- Language
- English
- Resource Type
- Journal article