Journal article
Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity
Brain research. Molecular brain research., Vol.129(1), pp.179-184
2004
Handle:
https://hdl.handle.net/2376/110211
PMID: 15469894
Abstract
Prolactin (PRL) and vasoactive intestinal polypeptide (VIP) mRNA levels were elevated in the brainstem of neuronal nitric oxide synthase (nNOS) gene knockout (KO) mice compared to the levels in nNOS control mice. In addition, PRL mRNA levels increased in the hypothalamus and the brainstem of nNOS control mice after administration of 7-nitro-indazole (7-NI), a relatively selective nNOS inhibitor. The results suggest that NO inhibits PRL. No differences in the genes measured were observed in inducible NOS KO mice.
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Details
- Title
- Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity
- Creators
- Lichao ChenPing TaishiDeborah DurickaJames M Krueger
- Publication Details
- Brain research. Molecular brain research., Vol.129(1), pp.179-184
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546912701842
- Language
- English
- Resource Type
- Journal article