Journal article
Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage
Proceedings of the National Academy of Sciences - PNAS, Vol.101(32), pp.11725-11730
From the Cover
08/10/2004
Handle:
https://hdl.handle.net/2376/112149
PMCID: PMC511012
PMID: 15289602
Abstract
A mutation in the canine multidrug resistance gene,
MDR1
, has previously been associated with drug sensitivities in two breeds from the collie lineage. We exploited breed phylogeny and reports of drug sensitivity to survey other purebred populations that might be genetically at risk. We found that the same allele,
mdr1-1
Δ, segregated in seven additional breeds, including two sighthounds that were not expected to share collie ancestry. A mutant haplotype that was conserved among affected breeds indicated that the allele was identical by descent. Based on breed histories and the extent of linkage disequilibrium, we conclude that all dogs carrying
mdr1-1
Δ are descendants of a dog that lived in Great Britain before the genetic isolation of breeds by registry (
ca.
1873). The breed distribution and frequency of
mdr1-1
Δ have applications in veterinary medicine and selective breeding, whereas the allele's history recounts the emergence of formally recognized breeds from an admixed population of working sheepdogs.
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Details
- Title
- Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage
- Creators
- Mark W Neff - Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616Kathryn R Robertson - Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616Aaron K Wong - Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616Noa Safra - Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616Karl W Broman - Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616Montgomery Slatkin - Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616Katrina L Mealey - Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616Niels C Pedersen - Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.101(32), pp.11725-11730
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Series
- From the Cover
- Publisher
- National Academy of Sciences
- Identifiers
- 99900547896701842
- Language
- English
- Resource Type
- Journal article