Bruchins: Insect-derived plant regulators that stimulate neoplasm formation

Robert P Doss; James E Oliver; William M Proebsting; Sandra W Potter; SreyReath Kuy; Stephen L Clement; R. Thomas Williamson; John R Carney; E. David DeVilbiss

doi:10.1073/pnas.110054697

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Bruchins: Insect-derived plant regulators that stimulate neoplasm formation

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Bruchins: Insect-derived plant regulators that stimulate neoplasm formation

Robert P Doss, James E Oliver, William M Proebsting, Sandra W Potter, SreyReath Kuy, Stephen L Clement, R. Thomas Williamson, John R Carney and E. David DeVilbiss

Proceedings of the National Academy of Sciences - PNAS, Vol.97(11), pp.6218-6223

05/23/2000

DOI: https://doi.org/10.1073/pnas.110054697

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https://hdl.handle.net/2376/106851

PMCID: PMC18585

PMID: 10811915

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Abstract

Biological Sciences

Pea weevil ( Bruchus pisorum L.) oviposition on pods of specific genetic lines of pea ( Pisum sativum L.) stimulates cell division at the sites of egg attachment. As a result, tumor-like growths of undifferentiated cells (neoplasms) develop beneath the egg. These neoplasms impede larval entry into the pod. This unique form of induced resistance is conditioned by the Np allele and mediated by a recently discovered class of natural products that we have identified from both cowpea weevil ( Callosobruchus maculatus F.) and pea weevil. These compounds, which we refer to as “bruchins,” are long-chain α,ω-diols, esterified at one or both oxygens with 3-hydroxypropanoic acid. Bruchins are potent plant regulators, with application of as little as 1 fmol (0.5 pg) causing neoplastic growth on pods of all of the pea lines tested. The bruchins are, to our knowledge, the first natural products discovered with the ability to induce neoplasm formation when applied to intact plants.

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Title: Bruchins: Insect-derived plant regulators that stimulate neoplasm formation
Creators: Robert P Doss - Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330; Departments of
James E Oliver - Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330; Departments of
William M Proebsting - Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330; Departments of
Sandra W Potter - Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330; Departments of
SreyReath Kuy - Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330; Departments of
Stephen L Clement - Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330; Departments of
R. Thomas Williamson - Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330; Departments of
John R Carney - Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330; Departments of
E. David DeVilbiss - Horticultural Crops Research Unit, United States Department of Agriculture, Agricultural Research Service, Corvallis, OR 97330; Departments of
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.97(11), pp.6218-6223
Academic Unit: UNKNOWN
Publisher: The National Academy of Sciences
Identifiers: 99900546991401842
Language: English
Resource Type: Journal article