Journal article
CRISPR-associated nucleases: the Dawn of a new age of efficient crop improvement
Transgenic research, Vol.29(1), pp.1-35
02/2020
Handle:
https://hdl.handle.net/2376/104518
PMID: 31677059
Abstract
The world stands at a new threshold today. As a planet, we face various challenges, and the key one is how to continue to produce enough food, feed, fiber, and fuel to support the burgeoning population. In the past, plant breeding and the ability to genetically engineer crops contributed to increasing food production. However, both approaches rely on random mixing or integration of genes, and the process can be unpredictable and time-consuming. Given the challenge of limited availability of natural resources and changing environmental conditions, the need to rapidly and precisely improve crops has become urgent. The discovery of CRISPR-associated endonucleases offers a precise yet versatile platform for rapid crop improvement. This review summarizes a brief history of the discovery of CRISPR-associated nucleases and their application in genome editing of various plant species. Also provided is an overview of several new endonucleases reported recently, which can be utilized for editing of specific genes in plants through various forms of DNA sequence alteration. Genome editing, with its ever-expanding toolset, increased efficiency, and its potential integration with the emerging synthetic biology approaches hold promise for efficient crop improvement to meet the challenge of supporting the needs of future generations.
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Details
- Title
- CRISPR-associated nucleases: the Dawn of a new age of efficient crop improvement
- Creators
- Rishikesh Ghogare - Washington State University, Pullman, USABruce Williamson-Benavides - Washington State University, Pullman, USAFabiola Ramírez-Torres - Washington State University, Pullman, USAAmit Dhingra - Washington State University, Pullman, USA. adhingra@wsu.edu
- Publication Details
- Transgenic research, Vol.29(1), pp.1-35
- Academic Unit
- Horticulture, Department of
- Publisher
- Netherlands
- Grant note
- WPN00011 / National Institute of Food and Agriculture
- Identifiers
- 99900546950901842
- Language
- English
- Resource Type
- Journal article