CYP2B6 mediates the in vitro hydroxylation of bupropion : Potential drug interactions with other antidepressants

Leah M HESSE; Karthik VENKATAKRISHNAN; Michael H COURT; Lisa L VON MOLTKE; S. U. X DUAN; Richard I SHADER; David J GREENBLATT

CYP2B6 mediates the in vitro hydroxylation of bupropion : Potential drug interactions with other antidepressants

Journal article

Peer reviewed

CYP2B6 mediates the in vitro hydroxylation of bupropion : Potential drug interactions with other antidepressants

Leah M HESSE, Karthik VENKATAKRISHNAN, Michael H COURT, Lisa L VON MOLTKE, S. U. X DUAN, Richard I SHADER and David J GREENBLATT

Drug metabolism and disposition, Vol.28(10), pp.1176-1183

2000

Handle:

https://hdl.handle.net/2376/114716

PMID: 10997936

Abstract

Psychology. Psychoanalysis. Psychiatry

Psychopharmacology

Pharmacology. Drug treatments

Biological and medical sciences

Medical sciences

Neuropharmacology

Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)

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Title: CYP2B6 mediates the in vitro hydroxylation of bupropion : Potential drug interactions with other antidepressants
Creators: Leah M HESSE - Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and the Division of Clinical Pharmacology, New England Medical Center, Boston, Massachusetts, United States
Karthik VENKATAKRISHNAN - Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and the Division of Clinical Pharmacology, New England Medical Center, Boston, Massachusetts, United States
Michael H COURT - Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and the Division of Clinical Pharmacology, New England Medical Center, Boston, Massachusetts, United States
Lisa L VON MOLTKE - Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and the Division of Clinical Pharmacology, New England Medical Center, Boston, Massachusetts, United States
S. U. X DUAN - Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and the Division of Clinical Pharmacology, New England Medical Center, Boston, Massachusetts, United States
Richard I SHADER - Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and the Division of Clinical Pharmacology, New England Medical Center, Boston, Massachusetts, United States
David J GREENBLATT - Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, and the Division of Clinical Pharmacology, New England Medical Center, Boston, Massachusetts, United States
Publication Details: Drug metabolism and disposition, Vol.28(10), pp.1176-1183
Academic Unit: Veterinary Clinical Sciences, Department of
Publisher: American Society for Pharmacology and Experimental Therapeutics; Bethesda, MD
Identifiers: 99900547851401842
Language: English
Resource Type: Journal article

CYP2B6 mediates the in vitro hydroxylation of bupropion : Potential drug interactions with other antidepressants

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