CaO--P2O5--Na2O-based sintering additives for hydroxyapatite (HAp) ceramics

S J Kalita; S Bose; H L Hosick; A Bandyopadhyay

doi:10.1016/j.biomaterials.2003.09.012

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CaO--P2O5--Na2O-based sintering additives for hydroxyapatite (HAp) ceramics

Journal article

Peer reviewed

CaO--P2O5--Na2O-based sintering additives for hydroxyapatite (HAp) ceramics

S J Kalita, S Bose, H L Hosick and A Bandyopadhyay

Biomaterials, Vol.25(12), pp.2331-2339

05/2004

DOI: https://doi.org/10.1016/j.biomaterials.2003.09.012

Handle:

https://hdl.handle.net/2376/103678

PMID: 14741598

Abstract

Cell Line

Molecular Weight

Sodium Compounds - chemistry

Cell Survival

Humans

Molecular Conformation

Osteoblasts - physiology

Oxides - chemistry

Cell Size

Durapatite - chemistry

Materials Testing

Hot Temperature

Hardness

Cell Adhesion

Phosphorus Compounds - chemistry

Compressive Strength

Ceramics - chemistry

Cell Division

Surface Properties

Resin Cements

Osteoblasts - cytology

Bone Substitutes - chemistry

Calcium Compounds - chemistry

We have assessed the effect of CaO--P2O5--Na2O-based sintering additives on mechanical and biological properties of hydroxyapatite (HAp) ceramics. Five different compositions of sintering additives were selected and prepared by mixing of CaO, P2O5, and Na2CO3 powders. 2.5 wt% of each additive was combined with commercial HAp powder, separately, followed by ball milling, and sintering at 1250 degrees C and 1300 degrees C in a muffle furnace. Green and sintered densities of the compacts were analyzed for the influence of additives on densification of HAp. Phase analyses were carried out using an X-ray diffractometer. Vickers microhardness testing was used to evaluate hardness of sintered compacts of different compositions. A maximum microhardness of 4.6 (+/- 0.28) GPa was attained for a composition with 2.5 wt% addition of CaO:P2O5:Na2O in the ratio of 3:3:4. Results from mechanical property evaluation showed that some of these sintering additives improved failure strength of HAp under compressive loading. Maximum compressive strength was observed for samples with 2.5 wt% addition of CaO. Average failure strength for this set of samples was calculated to be 220 (+/- 50) MPa. Cytotoxicity, and cell attachment studies were carried out using a modified human osteoblast cell line called OPC-1. In vitro results showed that these compositions were non-toxic. Some sintering aids enhanced cell attachment and proliferation, which was revealed from SEM examination of the scaffolds seeded with OPC-1 cells.

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Title: CaO--P2O5--Na2O-based sintering additives for hydroxyapatite (HAp) ceramics
Creators: S J Kalita - School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA
S Bose
H L Hosick
A Bandyopadhyay
Publication Details: Biomaterials, Vol.25(12), pp.2331-2339
Academic Unit: Mechanical and Materials Engineering, School of
Publisher: Netherlands
Identifiers: 99900546560701842
Language: English
Resource Type: Journal article

CaO--P2O5--Na2O-based sintering additives for hydroxyapatite (HAp) ceramics

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