Journal article
Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.274(1), pp.R168-R174
01/01/1998
Handle:
https://hdl.handle.net/2376/113813
PMID: 9458914
Abstract
Feeding rats a cafeteria diet results in increased food intake and excess sleep. Furthermore, vagal afferent activity is altered by a variety of gastrointestinal factors, and vagal stimulation can induce sleep. We investigated, therefore, the hypothesis that the vagal nerve plays a critical role in mediating the sleep-inducing effects of cafeteria feeding. We examined the effects of a cafeteria diet on sleep, electroencephalographic (EEG) slow-wave activity (SWA), and brain temperature (Tbr) in control and vagotomized rats. EEG, electromyogram, and Tbr were recorded for 7 consecutive days. Day 1 was considered a baseline day; normal rat chow was available ad libitum. On days 2- 4, the animals were fed, in addition to normal chow, a mixed, energy-rich diet (cafeteria diet). On days 5- 7, the rats were again fed only normal rat chow. In control rats, the cafeteria diet resulted in an increase in non-rapid eye movement sleep (NREMS), which was the result of a significant lengthening of the NREMS episodes. In contrast, feeding vagotomized rats the cafeteria diet resulted in a decrease in NREMS. Cafeteria feeding decreased REMS and EEG SWA and increased Tbr in both control and vagotomized rats. These results suggest that an intact vagus plays a key role in the NREMS-inducing effects of the cafeteria diet.
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Details
- Title
- Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats
- Creators
- Michael K Hansen - Department of Physiology and Biophysics, The University of Tennessee, Memphis, Memphis, Tennessee 38163Levente Kapás - Department of Physiology and Biophysics, The University of Tennessee, Memphis, Memphis, Tennessee 38163Jidong Fang - Department of Physiology and Biophysics, The University of Tennessee, Memphis, Memphis, Tennessee 38163James M Krueger - Department of Physiology and Biophysics, The University of Tennessee, Memphis, Memphis, Tennessee 38163
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.274(1), pp.R168-R174
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900548388301842
- Language
- English
- Resource Type
- Journal article