Journal article
Cafeteria feeding induces interleukin-1beta mRNA expression in rat liver and brain
The American journal of physiology, Vol.274(6), pp.R1734-R1739
06/1998
Handle:
https://hdl.handle.net/2376/113639
PMID: 9841485
Abstract
intake affects gut-immune function and can provide a strong intestinal antigen challenge resulting in activation of host defense mechanisms in the digestive system. Previously, we showed that feeding rats a cafeteria diet increases non-rapid eye movement sleep by a subdiaphragmatic mechanism. Food intake and sleep regulation and the immune system share the regulatory molecule interleukin-1beta (IL-1beta). Thus this study examined the effects of a cafeteria diet on IL-1beta mRNA and IL-1 receptor accessory protein (IL-1RAP) mRNA expression in rat liver and brain. Rats were fed normal rat chow or a palatable diet consisting of bread, chocolate, and shortbread cookies (cafeteria diet). After 3 days, midway between the light period of the light-dark cycle, rats were killed by decapitation. Feeding rats a cafeteria diet resulted in increased IL-1beta mRNA expression in the liver and hypothalamus compared with rats fed only the normal rat chow. In addition, cafeteria feeding decreased IL-1RAP mRNA levels in the liver and brain stem. These results indicate that feeding has direct effects on cytokine production and together with other data suggest that the increased sleep that accompanies increased feeding may be the result of increased brain IL-1beta. These results further suggest that cytokine-to-brain communication may be important in normal physiological conditions, such as feeding, as well as being important during inflammatory responses.
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Details
- Title
- Cafeteria feeding induces interleukin-1beta mRNA expression in rat liver and brain
- Creators
- M K Hansen - Department of Physiology and Biophysics, The University of Tennessee, Memphis, Tennessee 38163, USAP TaishiZ ChenJ M Krueger
- Publication Details
- The American journal of physiology, Vol.274(6), pp.R1734-R1739
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- NS-25378 / NINDS NIH HHS NS-27250 / NINDS NIH HHS NS-31453 / NINDS NIH HHS
- Identifiers
- 99900548390101842
- Language
- English
- Resource Type
- Journal article