Journal article
Calbindin expression in the hamster SCN is influenced by circadian genotype and by photic conditions
Neuroreport, Vol.10(15), pp.3159-3163
10/19/1999
Handle:
https://hdl.handle.net/2376/110292
PMID: 10574553
Abstract
CIRCADIAN rhythmicity in mammals, is controlled by the suprachiasmatic nuclei (SCN) of the hypothalamus. We previously described a discrete subnucleus in the core of the hamster SCN containing calbindin-D28k-positive cells which are fos-positive in response to a light pulse. Ablation of this subnucleus results in loss of circadian locomotor rhythmicity even when other parts of the SCN are spared. Here we show that Tau mutant hamsters have significantly more calbindin-D28k in the SCN than do wild type hamsters, and that SCN calbindin-immunoreactivity in the SCN increases in the dark. This is correlated with changes in magnitude of light mediated phase shifts in locomotion. The data are consistent with a role for calbindin cells in light mediated entrainment and phase shifting.
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Details
- Title
- Calbindin expression in the hamster SCN is influenced by circadian genotype and by photic conditions
- Creators
- Joseph LeSauter - 1Department of Psychology, Barnard College and Columbia University, Mail code 5501, 1190 Amsterdam Avenue, New York, NY 10027 2Department of Psychology, Columbia University and Department of Anatomy and Cell Biology, College of Physicians and Surgeons, New York, NY 10032 3Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267, USAPaula StevensHeiko JansenMichael LehmanRae Silver
- Publication Details
- Neuroreport, Vol.10(15), pp.3159-3163
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Lippincott Williams & Wilkins, Inc
- Identifiers
- 99900546904101842
- Language
- English
- Resource Type
- Journal article