Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review

Susmita Bose; Solaiman Tarafder

doi:10.1016/j.actbio.2011.11.017

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Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review

Journal article

Open access

Peer reviewed

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review

Susmita Bose and Solaiman Tarafder

Acta biomaterialia, Vol.8(4), pp.1401-1421

04/2012

DOI: https://doi.org/10.1016/j.actbio.2011.11.017

Handle:

https://hdl.handle.net/2376/107511

PMCID: PMC3418064

PMID: 22127225

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Abstract

Animals

Tissue Engineering - methods

Intercellular Signaling Peptides and Proteins - pharmacology

Humans

Hydroxyapatites - pharmacology

Intercellular Signaling Peptides and Proteins - administration & dosage

Drug Delivery Systems - methods

Calcium Phosphates - pharmacology

Bone and Bones - drug effects

Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility. In recent years, CaPs, especially hydroxyapatite and tricalcium phosphate, have attracted significant interest in simultaneous use as bone substitute and drug delivery vehicle, adding a new dimension to their application. CaPs are more biocompatible than many other ceramic and inorganic nanoparticles. Their biocompatibility and variable stoichiometry, thus surface charge density, functionality, and dissolution properties, make them suitable for both drug and growth factor delivery. CaP matrices and scaffolds have been reported to act as delivery vehicles for growth factors and drugs in bone tissue engineering. Local drug delivery in musculoskeletal disorder treatments can address some of the critical issues more effectively and efficiently than the systemic delivery. CaPs are used as coatings on metallic implants, CaP cements, and custom designed scaffolds to treat musculoskeletal disorders. This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.

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Title: Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review
Creators: Susmita Bose - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA. sbose@wsu.edu
Solaiman Tarafder
Publication Details: Acta biomaterialia, Vol.8(4), pp.1401-1421
Academic Unit: Mechanical and Materials Engineering, School of
Publisher: England
Grant note: R01 EB007351 / NIBIB NIH HHS R01-EB-007351 / NIBIB NIH HHS
Identifiers: 99900547256601842
Language: English
Resource Type: Journal article