Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

Gary A Wayman; Yong-Seok Lee; Hiroshi Tokumitsu; Alcino Silva; Thomas R Soderling

doi:10.1016/j.neuron.2008.08.021

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Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

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Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

Gary A Wayman, Yong-Seok Lee, Hiroshi Tokumitsu, Alcino Silva and Thomas R Soderling

Neuron (Cambridge, Mass.), Vol.59(6), pp.914-931

2008

DOI: https://doi.org/10.1016/j.neuron.2008.08.021

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https://hdl.handle.net/2376/104784

PMCID: PMC2664743

PMID: 18817731

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https://doi.org/10.1016/j.neuron.2008.08.021View

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Abstract

In the nervous system, many intracellular responses to elevated calcium are mediated by CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by binding Ca 2+/calmodulin and subsequently by protein phosphorylation. One member of this family, CaMKII, is well-established for its effects on modulating synaptic plasticity and learning and memory. However, recent studies indicate that some actions on neuronal development and function attributed to CaMKII may instead or in addition be mediated by other members of the CaMK cascade, such as CaMKK, CaMKI, and CaMKIV. This review summarizes key neuronal functions of the CaMK cascade in signal transduction, gene transcription, synaptic development and plasticity, and behavior. The technical challenges of mapping cellular protein kinase signaling pathways are also discussed.

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Title: Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity
Creators: Gary A Wayman - Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Yong-Seok Lee - Department of Neurobiology, University of California, Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA
Hiroshi Tokumitsu - Department of Signal Transduction Sciences, Kagawa University, Kagawa 761-0793, Japan
Alcino Silva - Department of Neurobiology, University of California, Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA
Thomas R Soderling - Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Publication Details: Neuron (Cambridge, Mass.), Vol.59(6), pp.914-931
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: Elsevier Inc
Identifiers: 99900546873401842
Language: English
Resource Type: Journal article