Journal article
Canine Cytochrome P-450 Pharmacogenetics
The Veterinary clinics of North America. Small animal practice, Vol.43(5), pp.1027-1038
09/2013
Handle:
https://hdl.handle.net/2376/115594
PMID: 23890236
Abstract
The cytochrome P-450 (CYP) drug metabolizing enzymes are essential for the efficient elimination of many clinically used drugs. These enzymes typically display high interindividual variability in expression and function resulting from enzyme induction, inhibition, and genetic polymorphism thereby predisposing patients to adverse drug reactions or therapeutic failure. There are also substantial species differences in CYP substrate specificity and expression that complicate direct extrapolation of information from humans to veterinary species. This article reviews the available published data regarding the presence and impact of genetic polymorphisms on CYP-dependent drug metabolism in dogs in the context of known human-dog CYP differences.
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Details
- Title
- Canine Cytochrome P-450 Pharmacogenetics
- Creators
- Michael H Court - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, 100 Grimes Way, Pullman, WA 99164, USA
- Publication Details
- The Veterinary clinics of North America. Small animal practice, Vol.43(5), pp.1027-1038
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Publisher
- Elsevier Inc
- Grant note
- Veterinary Medicine at Washington State University
- Identifiers
- 99900547404101842
- Language
- English
- Resource Type
- Journal article