Journal article
Catalytic asymmetric exo-selective [C+NC+CC] reaction
Organic letters, Vol.16(6), pp.1550-1553
03/21/2014
Handle:
https://hdl.handle.net/2376/107095
PMID: 24601876
Abstract
A catalytic asymmetric version of the exo-selective [C+NC+CC] reaction is reported. This multicomponent reaction utilizes a readily prepared achiral glycyl sultam as the "NC" component and commercially available catalyst components. The method can be applied to a variety of aldehydes ("C" component) and activated alkenes ("CC" component) to provide substituted pyrrolidines in good yields and high enantioselectivities. Of particular note is the ability to employ labile enolizable aldehydes (e.g., acetaldehyde and propionaldehyde) in this reaction.
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Details
- Title
- Catalytic asymmetric exo-selective [C+NC+CC] reaction
- Creators
- Ryan Joseph - Department of Chemistry, Washington State University , Pullman, Washington 99164-4630, United StatesCharles MurrayPhilip Garner
- Publication Details
- Organic letters, Vol.16(6), pp.1550-1553
- Academic Unit
- Chemistry, Department of
- Publisher
- United States
- Identifiers
- 99900546606201842
- Language
- English
- Resource Type
- Journal article