Cell membrane-formed nanovesicles for disease-targeted delivery

Jin Gao; Dafeng Chu; Zhenjia Wang

doi:10.1016/j.jconrel.2016.01.024

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Cell membrane-formed nanovesicles for disease-targeted delivery

Journal article

Open access

Peer reviewed

Cell membrane-formed nanovesicles for disease-targeted delivery

Jin Gao, Dafeng Chu and Zhenjia Wang

Journal of controlled release, Vol.224, pp.208-216

02/28/2016

DOI: https://doi.org/10.1016/j.jconrel.2016.01.024

Handle:

https://hdl.handle.net/2376/104408

PMCID: PMC4747686

PMID: 26778696

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https://doi.org/10.1016/j.jconrel.2016.01.024View

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Abstract

Targeted drug delivery

Nanovesicles

Vascular inflammation

Vascular inflammation is the underlying component of most diseases. To target inflamed vasculature, nanoparticles are commonly engineered by conjugating antibody to the nanoparticle surface, but this bottom-up approach could affect nanoparticle targeting and therapeutic efficacy in complex, physiologically related systems. During vascular inflammation endothelium via the NF-κB pathway instantly upregulates intercellular adhesion molecule 1 (ICAM-1) which binds integrin β2 on neutrophil membrane. Inspired by this interaction, we created a nanovesicle-based drug delivery system using nitrogen cavitation which rapidly disrupts activated neutrophils to make cell membrane nanovesicles. Studies using intravital microscopy of live mouse cremaster venules showed that these vesicles can selectively bind inflamed vasculature because they possess intact targeting molecules of integrin β2. Administering of nanovesicles loaded with TPCA-1 (a NF-κB inhibitor) markedly mitigated mouse acute lung inflammation. Our studies reveal a new top-down strategy for directly employing a diseased tissue to produce biofunctional nanovesicle-based drug delivery systems potentially applied to treat various diseases. [Display omitted]

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Title: Cell membrane-formed nanovesicles for disease-targeted delivery
Creators: Jin Gao - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA 99202, USA
Dafeng Chu - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA 99202, USA
Zhenjia Wang - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA 99202, USA
Publication Details: Journal of controlled release, Vol.224, pp.208-216
Academic Unit: Pharmaceutical Sciences, Department of
Publisher: Elsevier B.V
Identifiers: 99900546507001842
Language: English
Resource Type: Journal article