Journal article
Cellular and Molecular Implications of Mature Adipocyte Dedifferentiation
Journal of genomics, Vol.1, pp.5-12
2013
Handle:
https://hdl.handle.net/2376/117023
PMCID: PMC4091435
PMID: 25031650
Abstract
There is a voluminous amount of scientific literature dealing with the involvement of adipocytes in molecular regulation of carcass composition, obesity, metabolic syndrome, or diabetes. To form adipocytes (process termed adipogenesis) nearly all scientific papers refer to the use of preadipocytes, adipofibroblasts, stromal vascular cells or adipogenic cell lines, and their differentiation to form lipid-assimilating cells containing storage triacylglyceride. However, mature adipocytes, themselves, possess ability to undergo dedifferentiation, form proliferative-competent progeny cells (the exact plasticity is unknown) and reinitiate formation of cells capable of lipid metabolism and storage. The progeny cells would make a viable (and alternative) cell system for the evaluation of cell ability to reestablish lipid assimilation, ability to differentially express genes (as compared to other adipogenic cells), and to form other types of cells (multi-lineage potential). Understanding the dedifferentiation process itself and/or dedifferentiated fat cells could contribute to our knowledge of normal growth processes, or to disease function. Indeed, the ability of progeny cells to form other cell types could turn-out to be important for processes of tissue reconstruction/engineering and may have implications in clinical, biochemical or molecular processes.
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Details
- Title
- Cellular and Molecular Implications of Mature Adipocyte Dedifferentiation
- Creators
- Shengjuan Wei - 1. College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi Province 712100, ChinaMarcio S Duarte - 2. Department of Animal Sciences, Washington State University, Pullman, WA 99164, USALinsen Zan - 1. College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi Province 712100, ChinaMin Du - 2. Department of Animal Sciences, Washington State University, Pullman, WA 99164, USAZhihua Jiang - 2. Department of Animal Sciences, Washington State University, Pullman, WA 99164, USALeLuo Guan - 4. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta T6G 2P5, CanadaJie Chen - 5. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaGary J Hausman - 6. United States Department of Agriculture, Agriculture Research Services, Athens, GA 30605, USAMichael V Dodson - 2. Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA
- Publication Details
- Journal of genomics, Vol.1, pp.5-12
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Ivyspring International Publisher; Sydney
- Identifiers
- 99900548368101842
- Language
- English
- Resource Type
- Journal article