Journal article
Cellular signaling pathways regulating the initial stage of adipogenesis and marbling of skeletal muscle
Meat science, Vol.86(1), pp.103-109
2010
Handle:
https://hdl.handle.net/2376/113169
PMID: 20510530
Abstract
Due to extensive efforts to increase lean growth, intramuscular fat (marbling) is reducing in beef, pork and chicken breast, which impairs the eating quality of meat. Because fat is the major contributor to meat flavor, the presence of intramuscular fat is indispensible for the high eating quality of meat. However, up to now, our understanding of adipogenesis (formation of fat cells) in skeletal muscle is limited. Adipocyte differentiation in skeletal muscle initiates from multipotent mesenchymal stem cells, which are abundant in skeletal muscle at early developmental stages. In this review, the known cellular mechanisms regulating adipogenesis from multipotent cells are summarized, which include hedgehog, Wingless and Int (Wnt)/β-catenin, and bone morphogenesis protein (BMP) mediated signaling pathways, as well as AMP-activated protein kinase. Promoting adipogenesis within skeletal muscle will effectively increase intramuscular fat, improving the quality of meat.
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Details
- Title
- Cellular signaling pathways regulating the initial stage of adipogenesis and marbling of skeletal muscle
- Creators
- Min Du - Department of Animal Science, University of Wyoming, Laramie, WY 82071, USAJingdong Yin - College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaMei J Zhu - Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA
- Publication Details
- Meat science, Vol.86(1), pp.103-109
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900548364101842
- Language
- English
- Resource Type
- Journal article