Journal article
Central administration of neuropeptide Y induces wakefulness in rats
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.291(2), pp.R473-480
08/2006
Handle:
https://hdl.handle.net/2376/116691
PMID: 16914434
Abstract
Neuropeptide Y (NPY) is a well-characterized neuromodulator in the central nervous system, primarily implicated in the regulation of feeding. NPY, orexins, and ghrelin form a hypothalamic food intake regulatory circuit. Orexin and ghrelin are also implicated in sleep-wake regulation. In the present experiments, we studied the sleep-modulating effects of central administration of NPY in rats. Rats received intracerebroventricular injection of physiological saline or three different doses of NPY (0.4, 2, and 10 microg in a volume of 4 microl) at light onset. Another group of rats received bilateral microinjection of saline or 2 microg NPY in the lateral hypothalamus in a volume of 0.2 microl. Sleep-wake activity and motor activity were recorded for 23 h. Food intake after the control and treatment injections was also measured on separate days. Intracerebroventricular and lateral hypothalamic administration of NPY suppressed non-rapid-eye-movement sleep and rapid-eye-movement sleep in rats during the first hour after the injection and also induced changes in electroencephalogram delta power spectra. NPY stimulated food intake in the first hour after both routes of administration. Data are consistent with the hypothesis that NPY has a role in the integration of feeding, metabolism, and sleep regulation.
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Details
- Title
- Central administration of neuropeptide Y induces wakefulness in rats
- Creators
- E Szentirmai - Department of Physiology, University of Szeged, HungaryJ M Krueger
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.291(2), pp.R473-480
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- NS-27250 / NINDS NIH HHS
- Identifiers
- 99900547337701842
- Language
- English
- Resource Type
- Journal article