Journal article
Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk
International journal of epidemiology, Vol.39(1), pp.182-196
02/2010
Handle:
https://hdl.handle.net/2376/116744
PMCID: PMC2817090
PMID: 19805488
Abstract
Background
Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers.
Methods
We pooled individual-level data from case–control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models.
Results
Quitting tobacco smoking for 1–4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61–0.81 compared with current smoking], with the risk reduction due to smoking cessation after ≥20 years (OR 0.23, CI 0.18–0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after ≥20 years of quitting (OR 0.60, CI 0.40–0.89 compared with current drinking), reaching the level of never drinkers.
Conclusions
Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.
Metrics
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Details
- Title
- Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk
- Creators
- Manuela Marron - International Agency for Research on Cancer, Lyon, FrancePhilip Lazarus - Penn State College of Medicine, Hershey, PA, USAPaolo Boffetta - International Agency for Research on Cancer, Lyon, FranceZuo-Feng Zhang - UCLA School of Public Health, Los Angeles, CA, USADavid Zaridze - Cancer Research Centre, Moscow, RussiaVictor Wünsch-Filho - Universidade de Sao Paulo, Sao Paulo, BrazilDeborah M Winn - National Cancer Institute, Bethesda, MD, USAQingyi Wei - UT-M.D. Anderson Cancer Center, Houston, TX, USARenato Talamini - Aviano Cancer Centre, Aviano, ItalyNeonila Szeszenia-Dabrowska - Institute of Occupational Medicine, Lodz, PolandErich M Sturgis - UT-M.D. Anderson Cancer Center, Houston, TX, USAElaine Smith - College of Public Health, University of Iowa, Iowa City, IA, USAStephen M Schwartz - Fred Hutchinson Cancer Research Center, Seattle, WA, USAPeter Rudnai - National Institute of Environmental Health, Budapest, HungaryMark P Purdue - National Cancer Institute, Bethesda, MD, USAAndrew F Olshan - UNC School of Public Health, Chapel Hill, NC, USAJose Eluf-Neto - Universidade de Sao Paulo, Sao Paulo, BrazilJoshua Muscat - Penn State College of Medicine, Hershey, PA, USAHal Morgenstern - University of Michigan School of Public Health and Comprehensive Cancer Center, Ann Arbor, MI, USAAna Menezes - Universidade Federal de Pelotas, Pelotas, BrazilMichael McClean - Boston University, Boston, MA, USAElena Matos - Institute of Oncology Angel H. Roffo, University of Buenos Aires, ArgentinaIoan Nicolae Mates - University of Medicine and Pharmacy, Carol Davila, Bucharest, RomaniaJolanta Lissowska - The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Prevention, Warsaw, PolandFabio Levi - Institut Universitaire de Médecine Sociale et Préventive (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, SwitzerlandCarlo La Vecchia - Istituto di Ricerche Farmacologiche Mario Negri and University of Milan, Milan, ItalySergio Koifman - Escola Nacional de Saude Publica, Rio de Janeiro, BrazilKarl Kelsey - Brown University, Boston, MA, USARolando Herrero - Instituto de Investigación Epidemiológica, San José, Costa RicaRichard B Hayes - New York University School of Medicine, New York, NY, USASilvia Franceschi - International Agency for Research on Cancer, Lyon, FranceLeticia Fernandez - Institute of Oncology and Radiobiology, Havana, CubaEleonora Fabianova - Regional Authority of Public Health in Banská Bystrica, SlovakiaAlexander W Daudt - Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilLuigino Dal Maso - Aviano Cancer Centre, Aviano, ItalyMaria Paula Curado - International Agency for Research on Cancer, Lyon, FranceGabriella Cadoni - Università Cattolica del Sacro Cuore, Rome, ItalyChu Chen - Fred Hutchinson Cancer Research Center, Seattle, WA, USAXavier Castellsague - Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L’Hospitalet de Llobregat, SpainStefania Boccia - Università Cattolica del Sacro Cuore, Rome, ItalySimone Benhamou - INSERM U794, Paris, FranceGilles Ferro - International Agency for Research on Cancer, Lyon, FranceJulien Berthiller - International Agency for Research on Cancer, Lyon, FrancePaul Brennan - International Agency for Research on Cancer, Lyon, FranceHenrik Møller - King's College London, School of Medicine, Thames Cancer Registry, London, UKMia Hashibe - International Agency for Research on Cancer, Lyon, France
- Publication Details
- International journal of epidemiology, Vol.39(1), pp.182-196
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- Oxford University Press
- Number of pages
- 15
- Identifiers
- 99900547721101842
- Language
- English
- Resource Type
- Journal article