Journal article
Channeling satiation: a primer on the role of TRP channels in the control of glutamate release from vagal afferent neurons
Physiology & behavior, Vol.136, pp.179-184
09/2014
Handle:
https://hdl.handle.net/2376/112705
PMCID: PMC4287358
PMID: 25290762
Abstract
Obesity results from the chronic imbalance between food intake and energy expenditure. To maintain homeostasis, the brainstem nucleus of the solitary tract (NTS) integrates peripheral information from visceral organs and initiates reflex pathways that control food intake and other autonomic functions. This peripheral-to-central neural communication occurs through activation of vagal afferent neurons which converge to form the solitary tract (ST) and synapse with strong glutamatergic contacts onto NTS neurons. Vagal afferents release glutamate containing vesicles via three distinct pathways (synchronous, asynchronous, and spontaneous) providing multiple levels of control through fast synaptic neurotransmission at ST-NTS synapses. While temperature at the NTS is relatively constant, vagal afferent neurons express an array of thermosensitive ion channels named transient receptor potential (TRP) channels. Here we review the evidence that TRP channels pre-synaptically control quantal glutamate release and examine the potential roles of TRP channels in vagally mediated satiety signaling. We summarize the current literature that TRP channels contribute to asynchronous and spontaneous release of glutamate which can distinctly influence the transfer of information across the ST-NTS synapse. In other words, multiple glutamate vesicle release pathways, guided by afferent TRP channels, provide for robust while adaptive neurotransmission and expand our understanding of vagal afferent signaling.
Metrics
4 Record Views
Details
- Title
- Channeling satiation: a primer on the role of TRP channels in the control of glutamate release from vagal afferent neurons
- Creators
- Shaw-wen Wu - Dept. of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USAAxel J Fenwick - Dept. of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USAJames H Peters - Dept. of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA. Electronic address: jamespeters@vetmed.wsu.edu
- Publication Details
- Physiology & behavior, Vol.136, pp.179-184
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- DK092651 / NIDDK NIH HHS R01 DK092651 / NIDDK NIH HHS
- Identifiers
- 99900547724401842
- Language
- English
- Resource Type
- Journal article