Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics

Journal article

Open access

Peer reviewed

Dongxiao Sun, Gang Chen, Ryan W Dellinger, Arun K Sharma and Philip Lazarus

Pharmacogenetics and genomics, Vol.20(10), pp.575-585

10/2010

Handle:

https://hdl.handle.net/2376/101461

PMCID: PMC3076703

PMID: 20697310

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url

https://doi.org/10.1097/FPC.0b013e32833b04afView

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exemestane 17-dihydroexemestane

breast cancer

metabolism

UDP glucuronosyltransferase

glucuronidation

pharmacogenetics

aromatase inhibitor

11 Record Views

Title: Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics
Creators: Dongxiao Sun - Molecular Epidemiology and Cancer Control, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania, USA
Gang Chen - Molecular Epidemiology and Cancer Control, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania, USA
Ryan W Dellinger - Molecular Epidemiology and Cancer Control, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania, USA
Arun K Sharma - Chemical Carcinogenesis and Chemoprevention Programs, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania, USA
Philip Lazarus - Molecular Epidemiology and Cancer Control, Penn State Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania, USA
Publication Details: Pharmacogenetics and genomics, Vol.20(10), pp.575-585
Academic Unit: Pharmaceutical Sciences, Department of
Grant note: R01 DE013158-11 || DE / National Institute of Dental and Craniofacial Research : NIDCR
Identifiers: 99900546531601842
Language: English
Resource Type: Journal article