Journal article
Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/electrospray ionization mass spectrometry
Rapid communications in mass spectrometry, Vol.19(20), pp.2957-2964
2005
Handle:
https://hdl.handle.net/2376/104792
PMID: 16189817
Abstract
This study sought to determine the utility of liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) coupled with diode array detection in identifying gingerol-related compounds from crude extracts of ginger rhizome. The fragmentation behaviors of compounds in both (-)- and (+)ESI-MS/MS were used to infer and confirm the chemical structures of several groups of compounds, including the gingerols, methylgingerols, gingerol acetates, shogaols, paradols, gingerdiols, mono- and diacetyl gingerdiols, and dehydrogingerdiones. Diode array detection at different wavelengths was used to confirm MS/MS-based identification. In total, 31 gingerol-related compounds were identified from the methanolic crude extracts of fresh ginger rhizome in this study. Three of these compounds were found to be new compounds. This study demonstrated that LC/ESI-MS/MS is a powerful on-line tool for identification of gingerol-related compounds, especially for thermally labile compounds that cannot be readily detected by GC/MS analysis.
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Details
- Title
- Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/electrospray ionization mass spectrometry
- Creators
- Hongliang Jiang - Arizona Center for Phytomedicine Research, University of Arizona, Tucson, AZ 85721-0036, USAAnikó M SólyomBarbara N TimmermannDavid R Gang
- Publication Details
- Rapid communications in mass spectrometry, Vol.19(20), pp.2957-2964
- Academic Unit
- Biological Chemistry, Institute of
- Publisher
- England
- Grant note
- 5 P50 AT 000474-05 / NCCIH NIH HHS 3 P50 AT 000474-03 S / NCCIH NIH HHS
- Identifiers
- 99900546858501842
- Language
- English
- Resource Type
- Journal article