Journal article
Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788
Brain research, Vol.415(2), pp.367-370
1987
Handle:
https://hdl.handle.net/2376/115081
PMID: 3111641
Abstract
Three experiments were carried out in rats to evaluate the analgesic effects of the benzodiazepine antagonist, Ro 15-1788. Expt. 1 demonstrated a diazepam reversible analgesic effect of Ro 15-1788 using the tail-flick test. Expt. 2 analyzed the effects of Ro 15-1788 in the hot-plate test at various doses. Low doses of Ro 15-1788 proved analgesia 20 min after drug injection, whereas high doses had no analgesic effect of the 20 min test, but were effective on the 50 min test. Expt. 3 demonstrated that the opiate antagonist, naloxone, had no effect on analgesia produced by Ro 15-1788 in the hot-plate test. The analgesic effects of Ro 15-1788 may be attributable to its reported anxiogenic properties.
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Details
- Title
- Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788
- Creators
- Michael M MorganEdward D LevinJohn C Liebeskind
- Publication Details
- Brain research, Vol.415(2), pp.367-370
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900548308601842
- Language
- English
- Resource Type
- Journal article