Charge and substituent effects on affinity and metabolism of benzbromarone-based CYP2C19 inhibitors

Journal article

Peer reviewed

Charles W LOCUSON, Hisashi SUZUKI, Allan E RETTIE and Jeffrey P JONES

Journal of medicinal chemistry, Vol.47(27), pp.6768-6776

2004

Handle:

https://hdl.handle.net/2376/113228

PMID: 15615526

Abstract

Biological and medical sciences

Medical sciences

General pharmacology

Pharmacology. Drug treatments

Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions

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Title: Charge and substituent effects on affinity and metabolism of benzbromarone-based CYP2C19 inhibitors
Creators: Charles W LOCUSON - School of Molecular Biosciences, Washington State University, Pullman, Washington, 99164, United States
Hisashi SUZUKI - Meiji Seika Kaisha, Ltd., Pharmaceutical Research Center, Pharmacokin, 760 Morooka-cho, Kohoku-ku, Yokohama, 222-8567, Japan
Allan E RETTIE - Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195-7610, United States
Jeffrey P JONES - Department of Chemistry, Washington State University, P.O. Box 644630, Pullman, Washington 99164-4630, United States
Publication Details: Journal of medicinal chemistry, Vol.47(27), pp.6768-6776
Academic Unit: Chemistry, Department of
Publisher: American Chemical Society; Washington, DC
Identifiers: 99900548304601842
Language: English
Resource Type: Journal article