Chemical screening for hair cell loss and protection in the zebrafish lateral line

Allison B Coffin; Henry Ou; Kelly N Owens; Felipe Santos; Julian A Simon; Edwin W Rubel; David W Raible

doi:10.1089/zeb.2009.0639

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Chemical screening for hair cell loss and protection in the zebrafish lateral line

Journal article

Open access

Peer reviewed

Chemical screening for hair cell loss and protection in the zebrafish lateral line

Allison B Coffin, Henry Ou, Kelly N Owens, Felipe Santos, Julian A Simon, Edwin W Rubel and David W Raible

Zebrafish, Vol.7(1), pp.3-11

03/2010

DOI: https://doi.org/10.1089/zeb.2009.0639

Handle:

https://hdl.handle.net/2376/112483

PMCID: PMC2935285

PMID: 20192852

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https://doi.org/10.1089/zeb.2009.0639View

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Abstract

Cell Survival - drug effects

Hair Cells, Auditory - cytology

Hair Cells, Auditory - drug effects

Animals

Humans

Lateral Line System - drug effects

Zebrafish

Drug Evaluation, Preclinical

Drug Delivery Systems

Lateral Line System - cytology

In humans, most hearing loss results from death of hair cells, the mechanosensory receptors of the inner ear. Two goals of current hearing research are to protect hair cells from degeneration and to regenerate new hair cells, replacing those that are lost due to aging, disease, or environmental challenges. One limitation of research in the auditory field has been the relative inaccessibility of the mechanosensory systems in the inner ear. Zebrafish possess hair cells in both their inner ear and their lateral line system that are morphologically and functionally similar to human hair cells. The external location of the mechanosensory hair cells in the lateral line and the ease of in vivo labeling and imaging make the zebrafish lateral line a unique system for the study of hair cell toxicity, protection, and regeneration. This review focuses on the lateral line system as a model for understanding loss and protection of mechanosensory hair cells. We discuss chemical screens to identify compounds that induce hair cell loss and others that protect hair cells from known toxins and the potential application of these screens to human medicine.

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Title: Chemical screening for hair cell loss and protection in the zebrafish lateral line
Creators: Allison B Coffin - Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195-7923, USA. coffina@u.washington.edu
Henry Ou
Kelly N Owens
Felipe Santos
Julian A Simon
Edwin W Rubel
David W Raible
Publication Details: Zebrafish, Vol.7(1), pp.3-11
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: United States
Grant note: G35 / Action on Hearing Loss F32 DC009931-01 / NIDCD NIH HHS R01 DC009807 / NIDCD NIH HHS R01 DC005987 / NIDCD NIH HHS F32 DC009931 / NIDCD NIH HHS
Identifiers: 99900547538801842
Language: English
Resource Type: Journal article