Journal article
Chemically modified solid state nanopores for high throughput nanoparticle separation
Journal of physics. Condensed matter, Vol.22(45), pp.454107-454107
11/17/2010
Handle:
https://hdl.handle.net/2376/114089
PMID: 21339595
Abstract
The separation of biomolecules and other nanoparticles is a vital step in several analytical and diagnostic techniques. Towards this end we present a solid state nanopore-based set-up as an efficient separation platform. The translocation of charged particles through a nanopore was first modeled mathematically using the multi-ion model and the surface charge density of the nanopore membrane was identified as a critical parameter that determines the selectivity of the membrane and the throughput of the separation process. Drawing from these simulations a single 150 nm pore was fabricated in a 50 nm thick free-standing silicon nitride membrane by focused-ion-beam milling and was chemically modified with (3-aminopropyl)triethoxysilane to change its surface charge density. This chemically modified membrane was then used to separate 22 and 58 nm polystyrene nanoparticles in solution. Once optimized, this approach can readily be scaled up to nanopore arrays which would function as a key component of next-generation nanosieving systems.
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Details
- Title
- Chemically modified solid state nanopores for high throughput nanoparticle separation
- Creators
- Anmiv S Prabhu - School of Biomedical Engineering and Health Science, Drexel University, Philadelphia, PA 19104, USATalukder Zaki N JuberyKevin J FreedmanRafael MuleroPrashanta DuttaMin Jun Kim
- Publication Details
- Journal of physics. Condensed matter, Vol.22(45), pp.454107-454107
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- England
- Identifiers
- 99900547554401842
- Language
- English
- Resource Type
- Journal article