Journal article
Cholecystokinin activates both A- and C-type vagal afferent neurons
American journal of physiology: Gastrointestinal and liver physiology, Vol.285(6), pp.G1204-1213
12/2003
Handle:
https://hdl.handle.net/2376/103967
PMID: 12946940
Abstract
Patch-clamp electrophysiological methods were used on dissociated rat nodose neurons maintained in culture to determine whether responses to cholecystokinin (CCK) were associated with capsaicin-resistant (A type) or capsaicin-sensitive (C type) neurons. Nodose neurons were classified as A or C type on the basis of the characteristics of the Na+ current, a hyperpolarization-activated current, and sensitivity to a low concentration of capsaicin to ascertain the presence of vanilloid receptor 1 that has been associated with C-type neurons in sensory ganglia. It was expected that only capsaicin-sensitive C-type neurons would respond to CCK, because most vagally mediated actions of CCK are blocked by capsaicin treatment. However, we found that subpopulations of both A- and C-type neurons responded to CCK (24 and 38%, respectively). Thus some vagally mediated actions of CCK may be mediated by capsaicin insensitive A-type neurons.
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Details
- Title
- Cholecystokinin activates both A- and C-type vagal afferent neurons
- Creators
- Steven M Simasko - Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6520, USA. simasko@vetmed.wsu.eduRobert C Ritter
- Publication Details
- American journal of physiology: Gastrointestinal and liver physiology, Vol.285(6), pp.G1204-1213
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- NS-20561 / NINDS NIH HHS
- Identifiers
- 99900546651801842
- Language
- English
- Resource Type
- Journal article