Journal article
Chronic fatigue and chronic fatigue syndrome: A co-twin control study of functional status
Quality of life research, Vol.11(5), pp.463-471
08/2002
Handle:
https://hdl.handle.net/2376/106525
PMID: 12113393
Abstract
Chronic fatigue syndrome (CFS) and the symptom of chronic fatigue may be accompanied by substantial functional disability. A volunteer sample of twins discordant for fatigue was identified from throughout the US. Fatigued twins were classified using three increasingly stringent definitions: (1) ≥6 months of fatigue (119 pairs); (2) CFS-like illness based on self-report of the Centers for Disease Control and Prevention CFS research definition criteria (74 pairs); and (3) CFS assessed by clinical examination (22 pairs). Twins with chronic fatigue were compared with their unaffected co-twins on the eight standard scales and two physical and mental component summary scales from the medical outcomes study short-form health survey (SF-36). Substantial impairment was observed for fatigued twins across all levels of fatigue, while scores in the healthy twins were similar to US population values. Mean scores among fatigued twins on the physical and mental component summary scales were below 97 and 77%, respectively, of the US population scores. Diminished functional status was found across increasingly stringent classifications of fatigue and was associated with a dramatic decrement in physical functioning. The symptom of fatigue has a pronounced impact on functional status, especially in the domain of physical functioning.
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Details
- Title
- Chronic fatigue and chronic fatigue syndrome: A co-twin control study of functional status
- Creators
- Richard Herrell - The Division of Epidemiology-Biostatistics University of Illinois at Chicago Chicago IL USAJack Goldberg - The Vietnam Era Twin Registry Seattle WA USASuzanne Hartman - Department of Medicine University of Washington Seattle WA USAMegan Belcourt - Department of Medicine University of Washington Seattle WA USAKaren Schmaling - Department of Psychiatry and Behavioral Sciences University of Washington Seattle WA USADedra Buchwald - Department of Medicine University of Washington Seattle WA USA
- Publication Details
- Quality of life research, Vol.11(5), pp.463-471
- Academic Unit
- Community Health; Psychology, Department of
- Publisher
- Kluwer Academic Publishers; Dordrecht
- Identifiers
- 99900546814701842
- Language
- English
- Resource Type
- Journal article