Journal article
Clinical and immunologic response of cattle to administration of a vaccine containing modified-live bovine respiratory syncytial virus
Journal of the American Veterinary Medical Association, Vol.196(4), pp.583-589
02/15/1990
Handle:
https://hdl.handle.net/2376/116605
PMID: 1968056
Abstract
Healthy yearling beef and dairy cattle were inoculated with a vaccine containing modified-live bovine respiratory syncytial virus (ML-BRSV), and sequential changes in clinical signs of disease, blood leukocyte subsets, BRSV-specific antibody titer, and in vitro lymphocyte blastogenic responses were monitored. Vaccination with ML-BRSV did not cause pyrexia, local or systemic hypersensitivity reaction, or respiratory tract disease. Episodes of leukopenia, abnormalities in lymphocyte subsets, or depression of phytomitogen-induced blastogenic responses were not observed subsequent to vaccination. Exposure to ML-BRSV resulted in at least a 16-fold increase in serum neutralizing antibody titer, with no increase seen in nonvaccinated contact controls. Significant BRSV-specific lymphocyte blastogenic responses were not detected, using one dose of several BRSV antigen preparations in a whole blood culturing system.
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Details
- Title
- Clinical and immunologic response of cattle to administration of a vaccine containing modified-live bovine respiratory syncytial virus
- Creators
- J A Ellis - Department of Veterinary Sciences, College of Agriculture, University of Wyoming, Laramie 82070W C DavisL TalensD L Pratt
- Publication Details
- Journal of the American Veterinary Medical Association, Vol.196(4), pp.583-589
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- United States
- Identifiers
- 99900547930901842
- Language
- English
- Resource Type
- Journal article