Journal article
Clonal Mature Adipocyte Production of Proliferative-competent Daughter Cells Requires Lipid Export Prior to Cell Division
International journal of stem cells, Vol.2(1), pp.76-78
05/2009
Handle:
https://hdl.handle.net/2376/107224
PMID: 24855523
Abstract
Numerous in vitro observations have been published to show that mature adipocytes may resume proliferation and begin to populate the adipofibroblast fraction or form other cell types.
In the present study, we evaluated clonal cultures of mature pig-derived adipocytes as they began to reestablish their ability to divide. The lipid contained within the cytoplasm was either moved to the apical ends of the cell, or large droplets were physically extruded from the cell. In the latter case, we ascertained that the cell lipid droplet was handled in a different manner to that by beef-derived adipocytes as described in other published studies.
Pig-derived adipocytes expel large amounts of lipid directly into the medium environment prior to becoming capable of cell division, rather than retaining all lipids like the beef cells. This difference in lipid handling and trafficking may be a novel mechanism in adipocyte resumption of proliferation.
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Details
- Title
- Clonal Mature Adipocyte Production of Proliferative-competent Daughter Cells Requires Lipid Export Prior to Cell Division
- Creators
- Jie Chen - College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China ; Department of Animal Science, Washington State University, Pullman, WA 99164Maitea Guridi - Departamento de Producción Agraria, Universidad Pública de Navarra, Pamplona 31006 Navarra, SpainMelinda E Fernyhough - The Hartz Mountain Corporation, Bloomfield, NJ 07003Zhihua Jiang - Department of Animal Science, Washington State University, Pullman, WA 99164LeLuo Guan - Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada T6G 2P5Gary J Hausman - USDA-ARS, Richard B. Russell Agricultural Research Station, Athens, GA, 30604Michael V Dodson - Department of Animal Science, Washington State University, Pullman, WA 99164
- Publication Details
- International journal of stem cells, Vol.2(1), pp.76-78
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Korea (South)
- Identifiers
- 99900546815401842
- Language
- English
- Resource Type
- Journal article