Journal article
Clusterin in the male reproductive system: localization and possible function
Molecular and cellular endocrinology, Vol.151(1), pp.17-23
1999
Handle:
https://hdl.handle.net/2376/106448
PMID: 10411316
Abstract
Clusterin is a glycoprotein that was initially isolated from the male reproductive system. Subsequently, clusterin has been found to be widely distributed in a variety of tissues in mammals. One characteristic of the expression of clusterin is that it is induced as a result of cellular injury, death, or pathology. Despite the efforts of many laboratories working in diverse biological systems, the function of clusterin remains unknown. Recent studies have revealed a ‘heat-shock element’ in the promoter of the gene that may account for the inducible nature of the clusterin gene. Overall, the evidence suggests that function of clusterin is to protect surviving cells after damage. This protection may result from a detergent-like action of the protein.
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Details
- Title
- Clusterin in the male reproductive system: localization and possible function
- Creators
- Robert BaileyMichael D Griswold
- Publication Details
- Molecular and cellular endocrinology, Vol.151(1), pp.17-23
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900546980601842
- Language
- English
- Resource Type
- Journal article