Journal article
Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination
Nature cell biology, Vol.6(6), pp.555-562
06/2004
Handle:
https://hdl.handle.net/2376/117028
PMID: 15146193
Abstract
Sister chromatid cohesion ensures the faithful segregation of chromosomes in mitosis and in both meiotic divisions. Meiosis-specific components of the cohesin complex, including the recently described SMC1 isoform SMC1 beta, were suggested to be required for meiotic sister chromatid cohesion and DNA recombination. Here we show that SMC1 beta-deficient mice of both sexes are sterile. Male meiosis is blocked in pachytene; female meiosis is highly error-prone but continues until metaphase II. Prophase axial elements (AEs) are markedly shortened, chromatin extends further from the AEs, chromosome synapsis is incomplete, and sister chromatid cohesion in chromosome arms and at centromeres is lost prematurely. In addition, crossover-associated recombination foci are absent or reduced, and meiosis-specific perinuclear telomere arrangements are impaired. Thus, SMC1 beta has a key role in meiotic cohesion, the assembly of AEs, synapsis, recombination, and chromosome movements.
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Details
- Title
- Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination
- Creators
- Ekaterina Revenkova - Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USAMaureen EijpeChrista HeytingCraig A HodgesPatricia A HuntBodo LiebeHarry ScherthanRolf Jessberger
- Publication Details
- Nature cell biology, Vol.6(6), pp.555-562
- Publisher
- England
- Grant note
- HD37502 / NICHD NIH HHS GM62517 / NIGMS NIH HHS
- Identifiers
- 99900547913201842
- Language
- English
- Resource Type
- Journal article