Journal article
Cold water swim stress increases the expression of neurotensin mRNA in the lateral hypothalamus and medial preoptic regions of the rat brain
Brain research. Molecular brain research., Vol.86(1-2), pp.145-152
01/31/2001
Handle:
https://hdl.handle.net/2376/114189
PMID: 11165381
Abstract
Stress-induced analgesia is a well-documented phenomenon that occurs in all mammalian species. Forced cold water swim produces a type of stress-induced analgesia that is independent of mu opioid receptors. The neuropeptide neurotensin (NT) has been implicated in mu opioid-independent analgesia (MOIA), but the circuitry of this system is largely unknown. The medial preoptic area (MPO) and lateral hypothalamus (LH) are two regions that are known to modulate pain processing. These two regions also contain neurotensinergic projections to the periaqueductal gray, a region that has been shown to produce MOIA upon injection of NT. The goal of this study was to determine if cold water swim (CWS) stress, which produces MOIA, activates the NT–ergic systems in these two regions. In situ hybridization results indicate that CWS increases the level of NT mRNA within neurons in the MPO and LH, suggesting that these two regions are activated during this process.
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Details
- Title
- Cold water swim stress increases the expression of neurotensin mRNA in the lateral hypothalamus and medial preoptic regions of the rat brain
- Creators
- Karen A Seta - Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USAHeiko T Jansen - Department of Anatomy, Washington State University, Pullman, WA, USAK.Derek Kreitel - Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USAMichael Lehman - Departments of Cell Biology, Neurobiology and VCAPP, Center for Reproductive Biology, University of Cincinnati, Cincinnati, OH, USAMichael M Behbehani - Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA
- Publication Details
- Brain research. Molecular brain research., Vol.86(1-2), pp.145-152
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547555501842
- Language
- English
- Resource Type
- Journal article