Comparative endocrinology of leptin: Assessing function in a phylogenetic context

Richard L Londraville; Yazmin Macotela; Robert J Duff; Marietta R Easterling; Qin Liu; Erica J Crespi

doi:10.1016/j.ygcen.2014.02.002

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Comparative endocrinology of leptin: Assessing function in a phylogenetic context

Journal article

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Comparative endocrinology of leptin: Assessing function in a phylogenetic context

Richard L Londraville, Yazmin Macotela, Robert J Duff, Marietta R Easterling, Qin Liu and Erica J Crespi

General and comparative endocrinology, Vol.203, pp.146-157

07/01/2014

DOI: https://doi.org/10.1016/j.ygcen.2014.02.002

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https://hdl.handle.net/2376/113776

PMCID: PMC4128956

PMID: 24525452

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https://doi.org/10.1016/j.ygcen.2014.02.002View

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Abstract

Vertebrates

Fish

Immunology

Phylogeny

Amphibians

Leptin

•Leptin diversity within and among vertebrates is reviewed with a new phylogeny of leptins.•Leptin universally reduces appetite among all vertebrates tested, but does not reflect fat stores in fish.•Leptin is a stress-responsive hormone in multiple contexts and is an important immunomodulator throughout vertebrates.•Several comparative models offer opportunity for studying human disease. As we approach the end of two decades of leptin research, the comparative biology of leptin is just beginning. We now have several leptin orthologs described from nearly every major clade among vertebrates, and are moving beyond gene descriptions to functional studies. Even at this early stage, it is clear that non-mammals display clear functional similarities and differences with their better-studied mammalian counterparts. This review assesses what we know about leptin function in mammals and non-mammals, and gives examples of how these data can inform leptin biology in humans.

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Title: Comparative endocrinology of leptin: Assessing function in a phylogenetic context
Creators: Richard L Londraville - Department of Biology and Program in Integrated Biosciences, University of Akron, Akron, OH, USA
Yazmin Macotela - Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico
Robert J Duff - Department of Biology and Program in Integrated Biosciences, University of Akron, Akron, OH, USA
Marietta R Easterling - School of Biological Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
Qin Liu - Department of Biology and Program in Integrated Biosciences, University of Akron, Akron, OH, USA
Erica J Crespi - School of Biological Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
Publication Details: General and comparative endocrinology, Vol.203, pp.146-157
Academic Unit: Biological Sciences, School of
Publisher: Elsevier Inc
Identifiers: 99900547418801842
Language: English
Resource Type: Journal article