Journal article
Comparative genomic hybridization by microarray for the detection of cytogenetic imbalance
Methods in molecular medicine, Vol.128, pp.23-31
2006
Handle:
https://hdl.handle.net/2376/105946
PMID: 17071987
Abstract
Chromosomal abnormalities often result in the improper dosage of genes in a particular chromosome or chromosome segment, which may cause specific and complex clinical phenotypes. Comparative genomic hybridization by microarray (array CGH) is a high-throughput and high-resolution method for the detection of microscopic and submicroscopic chromosome abnormalities, some of which may not be detectable by conventional cytogenetic techniques. In addition, with the human genome sequenced and publicly available, array CGH allows for the direct correlation between chromosomal anomalies and genomic sequence. Properly constructed, microarrays have the potential to be a valuable tool for the detection of chromosomal abnormalities in cancer and genetic disease.
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Details
- Title
- Comparative genomic hybridization by microarray for the detection of cytogenetic imbalance
- Creators
- Malgorzata Jarmuz - Health Research and Education Center, Washington State University, Spokane, WA, USABlake C BallifCatherine D KashorkAaron P TheisenBassem A BejjaniLisa G Shaffer
- Publication Details
- Methods in molecular medicine, Vol.128, pp.23-31
- Academic Unit
- Center for Reproductive Biology; Medical Education and Clinical Science, Department of
- Publisher
- United States
- Identifiers
- 99900546752101842
- Language
- English
- Resource Type
- Journal article